Eliquis Study Reveals New Statistics
Several recent medical studies indicate that use of Eliquis as a blood thinner is not as safe as was originally claimed by the makers of the drug. The risk of bleeding is as great as with using the old standard of Coumadin (warfarin) if not greater.
In a study by Held and others from Sweden, a reanalysis was made of the pivotal ARISTOTLE study which formed the basis for FDA approval of Eliquis in 2012. The new analysis showed that major bleeds had occurred on the drug in 4.7% of users. Many of these bleeds were in the brain (intracranial), and of these a startling 43% of these patients died within 30 days of the bleed. Held C. Eur Heart J. 2014; doi:10.1093/eurheartj/ehu463.
In this study a major bleed was defined as one which needed two or more transfusions of blood to treat, or the hemocrit dropped 2 or more points.
In a study by Hess and others from Duke University, researchers investigated patients with heart attacks (acute coronary syndrome) who were given Eliquis to avoid the future development of clots, as part of a study known as the APPRIASE-2 trials. Not only did the drug not prevent damage, as compared to the use of aspirin and other anti-coagulants, but there was in fact increased bleeding. This led to sudden termination of the study. Hess et al. J Am Coll Cardiol. 2015;doi:10.1016.j.jacc.2015.06.027. See also the editorial on this study, Ruff CT. J Am Coll Cardiol. 2015;doi:10.1016.j.jacc.2015.06.1082.
Our firm is pursuing actions against Bristol-Myers Squibb and Pfizer Inc. for major bleeding events associated with the use of Eliquis (apixaban) as well as its sister drug Xarelto. The complaint we have filed points out concealments by these defendants from prescribing doctors and patients about irregularities in the clinical investigation of the drug, and the FDA concerns about the significance of missing data.
Have you or someone close to you been harmed by Eliquis or Xarelto? Please contact ustoday online or by telephone at (888) 260-0473 to speak with an experienced New York dangerous drugs liability law firm.